The popular, powerful, and hillarioans double-crossing mutant is a great challenge to Ultimate Spider-Man, as he is a mutant with powerful abilities.

Deadpool vs "Wally Webs"Edit

Deadpool, an often favorite of teenage Marvel Fans finds the fragment of Order and Chaos in the 8's level of the game.

Using the fragment, Deadpool tricks Ultimate Spider-Man into stepping into the cameras of his TV Show "Pain Factor".

After a big battle, and Spidey outruns Deadpool and finally steals the fragment, returning it to Madame Webb.